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KMID : 0369820000300020093
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Jorunal of Korean Pharmaceutical Sciences
2000 Volume.30 No. 2 p.93 ~ p.98
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The Effect of Fabrication Methods on the Release of Cefadroxil from a Polyurethane Matrix
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김승렬/Kim SR
이선희/김대덕/이치호/Lee SH/Kim DD/Lee CH
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Abstract
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In order to evaluate the effect of fabrication methods on the controlled release of an antibiotic from a polymeric device, two types of polyurethane-cefadroxil matrix were prepared by the solvent casting method or the freeze drying method, using bovine serum albumin as a pore former. The amount of cefadroxil released from various formulations at 37?C was measured by HPLC. The duration of antimicrobial activity of matrices against S. aureus was evaluated by measuring the diameters of the inhibition zone. The morphology of the matrices was investigated by scanning electron microscopy (SEM). Changing the fabrication method could alter the release rate of cefadroxil from the matrix. The matrix fabricated by the freeze drying method had more porous inner structure and showed higher release rate than that prepared by the solvent casting method. However, the duration of antimicrobial activity was shorter when the matrix was fabricated by the freeze drying method.
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KEYWORD
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Cefadroxil, Pore former, Fabrication method, Polyurethane, Controlled release
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